Stroke is the commonest cause of disability, second largest cause of dementia and third most frequent cause of death in the West. It currently consumes around 7% of the entire NHS budget and in the USA costs around $60 billion per year. Around 25% of all stroke patients are under the age of 65 years. Around the year 2050 WHO has estimated that approximately 80% of the world’s burden of stroke will lie within the emerging markets of India and China.
We have established BRAINS (Bio-Repository of DNA in Stroke) one of the largest stroke biobanks of patients from the Middle East and of South Asian stroke origins. Patients have been recruited from Qatar, multiple sites in the UK, India and also from Sri Lanka. Recently we have been awarded a large grant to startOur a dedicated DNA stroke repository in Qatar which is one of the first such repositories in the Middle East.
A considerable body of evidence from animal and human studies has demonstrated a convincing role for genetics in the aetiology of stroke. However, very little work has been undertaken in the Qatari population mainly hampered by the existence of a large, well characterized stroke repository.
One of the major objectives of our research programme is to establish a highly characterized DNA repository of stroke patients. All ethnic backgrounds are to be recruited only by Imperial College Healthcare NHS Trust and Bart’s and the London NHS Trust. All other study sites should recruit stroke patients and controls with South Asian background: Indian, Pakistani, Bangladeshi and any other Asian background (African Asian, Kashmiri Other, Nepali, Sri Lankan Sinhalese, Sri Lankan Tamil, Sri Lankan Other, Other Asian).
There is a genetic aetiology to sporadic ischaemic stroke. The British Repository of DNA in Stroke (BRAINS) is a platform for several arms for collecting DNA in patients with different cerebrovascular diseases including TIA, AVMs, ischaemic and haemorrhagic stroke. However, the genetics of such stroke in South Asians Qataris has been poorly investigated, partly as a result of few centres having access to enough subjects from this ethnic population group. This is despite the fact that South Asians Qataris people having a high vascular event rate.
Should you wish to join our research into stroke then please Contact us
Cerebral venous thrombosis (CVT) is an uncommon and a more rare form of stroke that affects less than 1% of all stroke patients. Mortality of CVT is very high, estimated to be 100 times higher compared to stroke in general. CVT affects in particular young adults and is more common in women (approximately two thirds of all patients). Although numerous aetiological risk factors have been reported, a significant proportion of cases have no obvious identified causes.
The BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) Consortium represents the largest global CVT study collaboration ever mounted and includes CVT patients from across Europe and North and South America. The study aims to understand why people get CVT, what makes them at risk, and to see if we can predict their likely outcome. Therefore, this study will provide a better understanding of the biological mechanisms underlying this unusual but very important cause of stroke in young (mainly female) adults and could lead to better prediction, as well as to discovery of specific treatments. Should you wish to join our research into BEAST then please Contact us